Brewing Master

Question:

However, as Ally correctly noted, inorganic phosphate does not play a role in the required step for glucose transport into the cell, namely conversion of glucose to glucose 6-phosphate (G6P) by hexokinase (HK).

I’m going back through this thread and apologizing. I was wrong. You were right. Somehow, I got it into my brain that glucose and inorganic phosphate magically linked up on the enzyme. Now that’s one of those mistakes that you later sit back and ask "What the hell were you thinking?" Oh well. Rob

Response:

What’s more, kinases take the phosphate they use off of ATP molecules to phosphorylate glucose, they don’t take it out of solution.

Ever make a mistake and later wonder how you could miss something so obvious? D’oh! So a sports drink loaded with free phosphate is unlikely to gain you anything.

This I’d have to disagree with you on. The consumption of inorganic phosphate has been shown to improve athletic performance in the lab. The why is still questionable. Not knowing why bugs me to no end, and between that and a few other distractions, I jumped to the wrong conclusion. I hate being wrong, but when I’m wrong, I try to own up to it. Rob

Response:

This I’d have to disagree with you on. The consumption of inorganic phosphate has been shown to improve athletic performance in the lab. The why is still questionable.

Improved oxygen transport via an increase in 2,3-diphosphoglycerate levels in haemoglobin was the initial suggestion (1984 and 1989 research). Anything been done on this since?

Response:

It’s been known that phosphate levels affect running for years.

I found a short section about phosphates in "Guide Nutritionnel des Sports d’Endurance" (D Rich